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This study investigates the effects of bio-mechanical filtration on the growth performance of Oreochromis niloticus and Brassica rapa within an Nutrient Film Technique aquaponic system, aiming to optimize productivity and water quality management. Aquaponics, a sustainable agricultural practice, integrates fish farming and hydroponic plant cultivation, creating a symbiotic ecosystem that requires careful balancing of nutrients and waste management. Bio-mechanical filtration, a technique that combines biological and mechanical processes to remove waste particles and improve water quality, has been identified as a critical factor for enhancing system efficiency. In this study, growth rates of Oreochromis niloticus and Brassica rapa were monitored under various filtration configurations to determine the impact of filtration efficiency on biomass production, nutrient availability, and overall system health. Results demonstrated that bio-mechanical filtration significantly improved water quality by reducing ammonia and nitrate levels, leading to higher growth rates in both Oreochromis niloticus and Brassica rapa. This study provides valuable insights for optimizing aquaponic system design, with implications for improving sustainability and scalability in urban and rural settings